Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells

Impaired degradation of the transcriptional coactivator YAP1 and IL6ST (interleukin 6 cytokine family signal transducer), two proteins deregulated in liver cancer, has been shown to promote tumor growth. Here, we demonstrate that YAP1 and IL6ST are novel substrates of chaperone-mediated autophagy (C...

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Detalles Bibliográficos
Autores principales: Desideri, Enrico, Castelli, Serena, Dorard, Coralie, Toifl, Stefanie, Grazi, Gian Luca, Ciriolo, Maria Rosa, Baccarini, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809932/
https://www.ncbi.nlm.nih.gov/pubmed/35435804
http://dx.doi.org/10.1080/15548627.2022.2063004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809932/
https://www.ncbi.nlm.nih.gov/pubmed/35435804
http://dx.doi.org/10.1080/15548627.2022.2063004

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