Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer

Dually targeting the epigenetic proteins lysine specific demethylase 1 (LSD1) and histone deacetylases (HDACs) that play a key role in cancer cells by modulating gene repressor complexes including CoREST will have a profound effect in inhibiting tumour growth. Here, we evaluated JBI-097 a dual LSD1/...

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Detalles Bibliográficos
Autores principales: Gajendran, Chandru, Tantry, Subramanyam Janardhan, M., Naveen Sadhu, Mohammed, Zainuddin, Dewang, Purushottam, Hallur, Mahanandeesha, Nair, Sreekala, Vaithilingam, Krishnakumar, Nagayya, Basavaprabhu, Rajagopal, Sridharan, Sivanandhan, Dhanalakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810167/
https://www.ncbi.nlm.nih.gov/pubmed/36595522
http://dx.doi.org/10.1371/journal.pone.0279063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810167/
https://www.ncbi.nlm.nih.gov/pubmed/36595522
http://dx.doi.org/10.1371/journal.pone.0279063

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