Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility

Multiple sclerosis (MS) is characterized by a targeted attack on oligodendroglia (OLG) and myelin by immune cells, which are thought to be the main drivers of MS susceptibility. We found that immune genes exhibit a primed chromatin state in single mouse and human OLG in a non-disease context, compat...

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Detalles Bibliográficos
Autores principales: Meijer, Mandy, Agirre, Eneritz, Kabbe, Mukund, van Tuijn, Cassandra A., Heskol, Abeer, Zheng, Chao, Falcão, Ana Mendanha, Bartosovic, Marek, Kirby, Leslie, Calini, Daniela, Johnson, Michael R., Corces, M. Ryan, Montine, Thomas J., Chen, Xingqi, Chang, Howard Y., Malhotra, Dheeraj, Castelo-Branco, Gonçalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810341/
https://www.ncbi.nlm.nih.gov/pubmed/35093191
http://dx.doi.org/10.1016/j.neuron.2021.12.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810341/
https://www.ncbi.nlm.nih.gov/pubmed/35093191
http://dx.doi.org/10.1016/j.neuron.2021.12.034

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