Cargando…

MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells

Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA damage and stress response, cellular metabolism, and aging....

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Yong Jung, Kwon, Young Hoon, Jang, Jung Yoon, Lee, Jun Ho, Lee, Sanggwon, Park, Yujin, Moon, Hyung Ryong, Chung, Hae Young, Kim, Nam Deuk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810441/ https://www.ncbi.nlm.nih.gov/pubmed/35811306 http://dx.doi.org/10.4062/biomolther.2022.044

Ejemplares similares

MHY2245, a Sirtuin Inhibitor, Induces Cell Cycle Arrest and Apoptosis in HCT116 Human Colorectal Cancer Cells
por: Kang, Yong Jung, et al.
Publicado: (2022)

Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells
por: Kim, Min Jeong, et al.
Publicado: (2020)

Pro-apoptotic effect of the novel benzylidene derivative MHY695 in human colon cancer cells
por: Heo, Gwangbeom, et al.
Publicado: (2019)

Evaluation of the Novel Synthetic Tyrosinase Inhibitor (Z)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) In Vitro and In Silico
por: Bang, EunJin, et al.
Publicado: (2018)

Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding
por: Park, Eun Young, et al.
Publicado: (2016)

MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling
por: Lamichane, Shreekrishna, et al.
Publicado: (2019)

MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells
por: Jang, Jung Yoon, et al.
Publicado: (2018)

Anticancer Effects of the Marine Sponge Lipastrotethya sp. Extract on Wild-Type and p53 Knockout HCT116 Cells
por: Choi, Kiheon, et al.
Publicado: (2017)

Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease
por: Lee, Seulah, et al.
Publicado: (2021)

A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells
por: Tae, In Hwan, et al.
Publicado: (2020)

Artemisia annua L. Polyphenol-Induced Cell Death Is ROS-Independently Enhanced by Inhibition of JNK in HCT116 Colorectal Cancer Cells
por: Jung, Eun Joo, et al.
Publicado: (2021)

Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
por: Choi, Yeon Ja, et al.
Publicado: (2012)

Correction: Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
por: Choi, Yeon Ja, et al.
Publicado: (2013)

Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells
por: Park, Hye Young, et al.
Publicado: (2017)

Hepatoprotective Effects of MHY3200 on High-Fat, Diet-Induced, Non-Alcoholic Fatty Liver Disease in Rats
por: Kim, Min Jo, et al.
Publicado: (2018)

Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells
por: Karabay, Arzu Zeynep, et al.
Publicado: (2016)

PPAR Pan Agonist MHY2013 Alleviates Renal Fibrosis in a Mouse Model by Reducing Fibroblast Activation and Epithelial Inflammation
por: Son, Minjung, et al.
Publicado: (2023)

NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT
por: Meng, Haining, et al.
Publicado: (2019)

Change in Expression of Survivin Caused by Using Oxaliplatin in HCT116 Colon Cancer Cells
por: Sohn, Won Jun, et al.
Publicado: (2010)

Thiobarbiturate-Derived Compound MHY1025 Alleviates Renal Fibrosis by Modulating Oxidative Stress, Epithelial Inflammation, and Fibroblast Activation
por: Kim, Jeongwon, et al.
Publicado: (2023)

Potent Anti-Diabetic Effects of MHY908, a Newly Synthesized PPAR α/γ Dual Agonist in db/db Mice
por: Park, Min Hi, et al.
Publicado: (2013)

A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation
por: De, Umasankar, et al.
Publicado: (2018)

A New Histone Deacetylase Inhibitor, MHY219, Inhibits the Migration of Human Prostate Cancer Cells via HDAC1
por: De, Umasankar, et al.
Publicado: (2015)

(2E,5E)-2,5-Bis(3-hydroxy-4-methoxybenzylidene) cyclopentanone Exerts Anti-Melanogenesis and Anti-Wrinkle Activities in B16F10 Melanoma and Hs27 Fibroblast Cells
por: Jung, Hee Jin, et al.
Publicado: (2018)

Characterization of sphere-forming HCT116 clones by whole RNA sequencing
por: Chung, Eunkyung, et al.
Publicado: (2016)

PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling
por: Kim, Min Jo, et al.
Publicado: (2021)

Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells
por: Kang, Ji In, et al.
Publicado: (2016)

2251 Assessing research impact: It takes a team
por: Dunn, Ashley, et al.
Publicado: (2018)

In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template
por: Choi, Inkyu, et al.
Publicado: (2020)

Mitochondrial dysfunction suppresses p53 expression via calcium-mediated nuclear factor-kB signaling in HCT116 human colorectal carcinoma cells
por: Lee, Young-Kyoung, et al.
Publicado: (2018)

Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines
por: Chowdhury, Sanjib, et al.
Publicado: (2013)

Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging
por: Kim, Seong Min, et al.
Publicado: (2017)

Cytoprotective Roles of a Novel Compound, MHY-1684, against Hyperglycemia-Induced Oxidative Stress and Mitochondrial Dysfunction in Human Cardiac Progenitor Cells
por: Jang, Woong Bi, et al.
Publicado: (2018)

MHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer
por: Chung, Jae Heun, et al.
Publicado: (2022)

The Novel PPAR α/γ Dual Agonist MHY 966 Modulates UVB–Induced Skin Inflammation by Inhibiting NF-κB Activity
por: Park, Min Hi, et al.
Publicado: (2013)

A New Histone Deacetylase Inhibitor, MHY4381, Induces Apoptosis via Generation of Reactive Oxygen Species in Human Prostate Cancer Cells
por: Richa, Sachan, et al.
Publicado: (2020)

Slug promotes p53 and p21 protein degradation by inducing Mdm2 expression in HCT116 colon cancer cells
por: Kim, Jongdoo, et al.
Publicado: (2021)

Coptidis Rhizoma Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase
por: Kang, Yong-Hwi, et al.
Publicado: (2021)

Peroxiredoxin-6 regulates p38-mediated epithelial–mesenchymal transition in HCT116 colon cancer cells
por: Chae, Unbin, et al.
Publicado: (2021)

Δ40p53 is involved in the inactivation of autophagy and contributes to inhibition of cell death in HCT116-Δ40p53 cells
por: Zang, Yunjin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mnlmfsat5tp5ggijudq6jfl9o9