A fast, efficient, and scalable method for purifying recombinant SARS-CoV-2 spike protein

Recombinant SARS-CoV-2 trimeric spike protein produced by mammalian cell culture is a potential candidate for a COVID-19 vaccine. However, this protein is much larger than most typical biopharmaceutical proteins and its large-scale manufacture is therefore challenging. Particularly, its purification...

Descripción completa

Detalles Bibliográficos
Autores principales: Butani, Nikhila, Xu, Yating, Pan, Si, Durocher, Yves, Ghosh, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810479/
https://www.ncbi.nlm.nih.gov/pubmed/36603473
http://dx.doi.org/10.1016/j.jchromb.2022.123579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810479/
https://www.ncbi.nlm.nih.gov/pubmed/36603473
http://dx.doi.org/10.1016/j.jchromb.2022.123579

Ejemplares similares