Common ABCB1 SNP, C3435T could affect systemic exposure of dapagliflozin in healthy subject

P-glycoprotein (P-gp) is a transporter that plays an excretory role in epithelial cells. It is encoded by ABCB1, and single nucleotide polymorphisms (SNPs) in this gene can affect systemic drug exposure. Dapagliflozin and sitagliptin, used in type 2 diabetes treatment, are P-gp substrates. Here, we...

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Detalles Bibliográficos
Autores principales: Hwang, Jun Gi, Jeong, Sae Im, Kim, Yu Kyong, Lee, Yujin, Ji, Sang Chun, Lee, SeungHwan, Park, Min Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Clinical Pharmacology and Therapeutics 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810488/
https://www.ncbi.nlm.nih.gov/pubmed/36632075
http://dx.doi.org/10.12793/tcp.2022.30.e23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810488/
https://www.ncbi.nlm.nih.gov/pubmed/36632075
http://dx.doi.org/10.12793/tcp.2022.30.e23

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