Cargando…
Predicting the systemic exposure and lung concentration of nafamostat using physiologically-based pharmacokinetic modeling
Nafamostat has been actively studied for its neuroprotective activity and effect on various indications, such as coronavirus disease 2019 (COVID-19). Nafamostat has low water solubility at a specific pH and is rapidly metabolized in the blood. Therefore, it is administered only intravenously, and it...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Korean Society for Clinical Pharmacology and Therapeutics
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810492/ https://www.ncbi.nlm.nih.gov/pubmed/36632076 http://dx.doi.org/10.12793/tcp.2022.30.e20 |