The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P(2) replenishment in response to TCR signaling during T cell development and survival

Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP(2)) by phospholipase C-γ (PLCγ1) represents a critical step in T cell antigen receptor (TCR) signaling and subsequent thymocyte and T cell responses. PIP(2) replenishment following its depletion in the plasma membrane (PM) is dependent on deli...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Wen, Helou, Ynes A., Shrinivas, Krishna, Liou, Jen, Au-Yeung, Byron B., Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810531/
https://www.ncbi.nlm.nih.gov/pubmed/36581712
http://dx.doi.org/10.1038/s41590-022-01372-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810531/
https://www.ncbi.nlm.nih.gov/pubmed/36581712
http://dx.doi.org/10.1038/s41590-022-01372-2

Ejemplares similares