A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia

The molecular regulation of human hematopoietic stem cell (HSC) maintenance is therapeutically important, but limitations in experimental systems and interspecies variation have constrained our knowledge of this process. Here, we have studied a rare genetic disorder due to MECOM haploinsufficiency,...

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Detalles Bibliográficos
Autores principales: Voit, Richard A., Tao, Liming, Yu, Fulong, Cato, Liam D., Cohen, Blake, Fleming, Travis J., Antoszewski, Mateusz, Liao, Xiaotian, Fiorini, Claudia, Nandakumar, Satish K., Wahlster, Lara, Teichert, Kristian, Regev, Aviv, Sankaran, Vijay G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810535/
https://www.ncbi.nlm.nih.gov/pubmed/36522544
http://dx.doi.org/10.1038/s41590-022-01370-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810535/
https://www.ncbi.nlm.nih.gov/pubmed/36522544
http://dx.doi.org/10.1038/s41590-022-01370-4

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