Vertebrate OTOP1 is also an alkali-activated channel

Although alkaline sensation is critical for survival, alkali-activated receptors are yet to be identified in vertebrates. Here, we showed that the OTOP1 channel can be directly activated by extracellular alkali. Notably, OTOP1 biphasically mediated proton influx and efflux with extracellular acid an...

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Detalles Bibliográficos
Autores principales: Tian, Lifeng, Zhang, Hao, Yang, Shilong, Luo, Anna, Kamau, Peter Muiruri, Hu, Jingmei, Luo, Lei, Lai, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810603/
https://www.ncbi.nlm.nih.gov/pubmed/36596786
http://dx.doi.org/10.1038/s41467-022-35754-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810603/
https://www.ncbi.nlm.nih.gov/pubmed/36596786
http://dx.doi.org/10.1038/s41467-022-35754-9

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