Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia

Transient receptor potential vanilloid 1 (TRPV1) ion channel is a classic analgesic target, but antagonists of TRPV1 failed in clinical trials due to their side effects like hyperthermia. Here we rationally engineer a peptide s-RhTx as a positive allosteric modulator (PAM) of TRPV1. Patch-clamp reco...

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Detalles Bibliográficos
Autores principales: Zhang, Heng, Lin, Jia-Jia, Xie, Ya-Kai, Song, Xiu-Zu, Sun, Jia-Yi, Zhang, Bei-Lei, Qi, Yun-Kun, Xu, Zhen-Zhong, Yang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810691/
https://www.ncbi.nlm.nih.gov/pubmed/36596769
http://dx.doi.org/10.1038/s41467-022-34817-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810691/
https://www.ncbi.nlm.nih.gov/pubmed/36596769
http://dx.doi.org/10.1038/s41467-022-34817-1

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