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Transcript shortening via alternative polyadenylation promotes gene expression during fracture healing

Maturation of the 3′ end of almost all eukaryotic messenger RNAs (mRNAs) requires cleavage and polyadenylation. Most mammalian mRNAs are polyadenylated at different sites within the last exon, generating alternative polyadenylation (APA) isoforms that have the same coding region but distinct 3′ untr...

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Detalles Bibliográficos
Autores principales: Khajuria, Deepak Kumar, Nowak, Irena, Leung, Ming, Karuppagounder, Vengadeshprabhu, Imamura, Yuka, Norbury, Christopher C., Kamal, Fadia, Elbarbary, Reyad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810729/
https://www.ncbi.nlm.nih.gov/pubmed/36596777
http://dx.doi.org/10.1038/s41413-022-00236-7