A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology

Hypertrophic cardiomyopathy is an inherited disorder due to mutations in contractile proteins that results in a stiff, hypercontractile myocardium. To understand the role of cardiac stiffness in disease progression, here we create an in vitro model of hypertrophic cardiomyopathy utilizing hydrogel t...

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Detalles Bibliográficos
Autores principales: Viola, Helena M., Richworth, Caitlyn, Solomon, Tanya, Chin, Ian L., Szappanos, Henrietta Cserne, Sundararaj, Srinivasan, Shishmarev, Dmitry, Casarotto, Marco G., Choi, Yu Suk, Hool, Livia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810744/
https://www.ncbi.nlm.nih.gov/pubmed/36596888
http://dx.doi.org/10.1038/s42003-022-04278-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810744/
https://www.ncbi.nlm.nih.gov/pubmed/36596888
http://dx.doi.org/10.1038/s42003-022-04278-9

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