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Enhancement of HSA-pFSHβ production by disrupting YPS1 and supplementing N-acetyl-L-cysteine in Pichia pastoris
INTRODUCTION: Pichia pastoris is widely used for the production of recombinant proteins, but the low production efficiency hinders its wide application in biopharmaceuticals. Moreover, many biopharmaceutical-like proteins are accompanied by degradation during secretory expression in P. pastoris. OBJ...
Autores principales: | Luo, Gang, Geng, Zijian, Kuerban, Buayisham, Xu, Yingqing, Yang, Jingjing, Liu, Jiying, Li, Muwang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810807/ https://www.ncbi.nlm.nih.gov/pubmed/36620033 http://dx.doi.org/10.3389/fmicb.2022.998647 |
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