PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells

PACSIN2 variants are associated with gastrointestinal effects of thiopurines and thiopurine methyltransferase activity through an uncharacterized mechanism that is postulated to involve autophagy. This study aims to clarify the role of PACSIN2 in autophagy and in thiopurine cytotoxicity in leukemic...

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Detalles Bibliográficos
Autores principales: Zudeh, Giulia, Franca, Raffaella, Lucafò, Marianna, Bonten, Erik J, Bramuzzo, Matteo, Sgarra, Riccardo, Lagatolla, Cristina, Franzin, Martina, Evans, William E, Decorti, Giuliana, Stocco, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811133/
https://www.ncbi.nlm.nih.gov/pubmed/36596605
http://dx.doi.org/10.26508/lsa.202201610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811133/
https://www.ncbi.nlm.nih.gov/pubmed/36596605
http://dx.doi.org/10.26508/lsa.202201610

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