NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin

[Image: see text] DNA viruses are responsible for many diseases in humans. Current treatments are often limited by toxicity, as in the case of cidofovir (CDV, Vistide), a compound used against cytomegalovirus (CMV) and adenovirus (AdV) infections. CDV is a polar molecule with poor bioavailability, a...

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Detalles Bibliográficos
Autores principales: Lipka, Elke, Chadderdon, Aaron M., Harteg, Cheryl C., Doherty, Matthew K., Simon, Eric S., Domagala, John M., Reyna, Dawn M., Hutchings, Kim M., Gan, Xinmin, White, Andrew D., Hartline, Caroll B., Harden, Emma A., Keith, Kathy A., Prichard, Mark N., James, Scott H., Cardin, Rhonda D., Bernstein, David I., Spencer, Jacqueline F., Tollefson, Ann E., Wold, William S. M., Toth, Karoly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811456/
https://www.ncbi.nlm.nih.gov/pubmed/36484496
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811456/
https://www.ncbi.nlm.nih.gov/pubmed/36484496
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00668

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