Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates

[Image: see text] The presence of amyloid fibrils of α-synuclein is closely associated with Parkinson’s disease and related synucleinopathies. It is still very challenging, however, to systematically discover small molecules that prevent the formation of these aberrant aggregates. Here, we describe...

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Detalles Bibliográficos
Autores principales: Chia, Sean, Faidon Brotzakis, Z., Horne, Robert I., Possenti, Andrea, Mannini, Benedetta, Cataldi, Rodrigo, Nowinska, Magdalena, Staats, Roxine, Linse, Sara, Knowles, Tuomas P. J., Habchi, Johnny, Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811465/
https://www.ncbi.nlm.nih.gov/pubmed/36374974
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811465/
https://www.ncbi.nlm.nih.gov/pubmed/36374974
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00548

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