Nucleoside analogs in ADAR guide strands targeting 5′-UA̲ sites

Adenosine deaminases that act on RNA (ADARs) can be directed to predetermined sites in transcriptomes by forming duplex structures with exogenously delivered guide RNAs (gRNAs). They can then catalyze the hydrolytic deamination of adenosine to inosine in double stranded RNA, which is read as guanosi...

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Detalles Bibliográficos
Autores principales: Brinkman, Hannah F., Jauregui Matos, Victorio, Mendoza, Herra G., Doherty, Erin E., Beal, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811522/
https://www.ncbi.nlm.nih.gov/pubmed/36685257
http://dx.doi.org/10.1039/d2cb00165a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811522/
https://www.ncbi.nlm.nih.gov/pubmed/36685257
http://dx.doi.org/10.1039/d2cb00165a

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