Dinuclear nitrido-bridged osmium complexes inhibit the mitochondrial calcium uniporter and protect cortical neurons against lethal oxygen–glucose deprivation

Dysregulation of mitochondrial calcium uptake mediated by the mitochondrial calcium uniporter (MCU) is implicated in several pathophysiological conditions. Dinuclear ruthenium complexes are effective inhibitors of the MCU and have been leveraged as both tools to study mitochondrial calcium dynamics...

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Detalles Bibliográficos
Autores principales: Woods, Joshua J., Novorolsky, Robyn J., Bigham, Nicholas P., Robertson, George S., Wilson, Justin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811523/
https://www.ncbi.nlm.nih.gov/pubmed/36685255
http://dx.doi.org/10.1039/d2cb00189f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811523/
https://www.ncbi.nlm.nih.gov/pubmed/36685255
http://dx.doi.org/10.1039/d2cb00189f

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