Selection methods for proximity-dependent enrichment of ligands from DNA-encoded libraries using enzymatic fusion proteins

Herein, we report a selection approach to enrich ligands from DNA-encoded libraries (DELs) based on proximity to an enzymatic tag on the target protein. This method involves uncaging or installation of a biotin purification tag on the DNA construct either through photodeprotection of a protected bio...

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Detalles Bibliográficos
Autores principales: Cai, Bo, Mhetre, Amol B., Krusemark, Casey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811540/
https://www.ncbi.nlm.nih.gov/pubmed/36687357
http://dx.doi.org/10.1039/d2sc05495g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811540/
https://www.ncbi.nlm.nih.gov/pubmed/36687357
http://dx.doi.org/10.1039/d2sc05495g

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