The Ras GTPase‐activating‐like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL‐1β release via exosomes

IL‐1β can exit the cytosol as an exosomal cargo following inflammasome activation in intestinal epithelial cells (IECs) in a Gasdermin D (GSDMD)‐dependent manner. The mechanistic connection linking inflammasome activation and the biogenesis of exosomes has so far remained largely elusive. Here, we r...

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Detalles Bibliográficos
Autores principales: Liao, Yun, Chen, Xing, Miller‐Little, William, Wang, Han, Willard, Belinda, Bulek, Katarzyna, Zhao, Junjie, Li, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811620/
https://www.ncbi.nlm.nih.gov/pubmed/36373462
http://dx.doi.org/10.15252/embj.2022110780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811620/
https://www.ncbi.nlm.nih.gov/pubmed/36373462
http://dx.doi.org/10.15252/embj.2022110780

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