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Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly

The amplitude of Wnt/β-catenin signaling is precisely controlled by the assembly of the cell surface–localized Wnt receptor signalosome and the cytosolic β-catenin destruction complex. How these two distinct complexes are coordinately controlled remains largely unknown. Here, we demonstrated that th...

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Detalles Bibliográficos
Autores principales: Kang, Kexin, Shi, Qiaoni, Wang, Xu, Chen, Ye-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811998/
https://www.ncbi.nlm.nih.gov/pubmed/36342472
http://dx.doi.org/10.1083/jcb.202205069