Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase

Human APOBEC3G (A3G) is a virus restriction factor that inhibits HIV-1 replication and triggers lethal hypermutation on viral reverse transcripts. HIV-1 viral infectivity factor (Vif) breaches this host A3G immunity by hijacking a cellular E3 ubiquitin ligase complex to target A3G for ubiquitination...

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Detalles Bibliográficos
Autores principales: Ito, Fumiaki, Alvarez-Cabrera, Ana L., Liu, Shiheng, Yang, Hanjing, Shiriaeva, Anna, Zhou, Z. Hong, Chen, Xiaojiang S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812381/
https://www.ncbi.nlm.nih.gov/pubmed/36598981
http://dx.doi.org/10.1126/sciadv.ade3168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812381/
https://www.ncbi.nlm.nih.gov/pubmed/36598981
http://dx.doi.org/10.1126/sciadv.ade3168

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