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Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase

Human APOBEC3G (A3G) is a virus restriction factor that inhibits HIV-1 replication and triggers lethal hypermutation on viral reverse transcripts. HIV-1 viral infectivity factor (Vif) breaches this host A3G immunity by hijacking a cellular E3 ubiquitin ligase complex to target A3G for ubiquitination...

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Detalles Bibliográficos
Autores principales:	Ito, Fumiaki, Alvarez-Cabrera, Ana L., Liu, Shiheng, Yang, Hanjing, Shiriaeva, Anna, Zhou, Z. Hong, Chen, Xiaojiang S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812381/ https://www.ncbi.nlm.nih.gov/pubmed/36598981 http://dx.doi.org/10.1126/sciadv.ade3168

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