Lactate metabolism is essential in early-onset mitochondrial myopathy

Myopathies secondary to mitochondrial electron transport chain (ETC) dysfunction can result in devastating disease. While the consequences of ETC defects have been extensively studied in culture, little in vivo data are available. Using a mouse model of severe, early-onset mitochondrial myopathy, we...

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Detalles Bibliográficos
Autores principales: Chen, Zhenkang, Bordieanu, Bogdan, Kesavan, Rushendhiran, Lesner, Nicholas P., Venigalla, Siva Sai Krishna, Shelton, Spencer D., DeBerardinis, Ralph J., Mishra, Prashant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812384/
https://www.ncbi.nlm.nih.gov/pubmed/36598990
http://dx.doi.org/10.1126/sciadv.add3216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812384/
https://www.ncbi.nlm.nih.gov/pubmed/36598990
http://dx.doi.org/10.1126/sciadv.add3216

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