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CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state–sensitive manner
CLASPs (cytoplasmic linker-associated proteins) are ubiquitous stabilizers of microtubule dynamics, but their molecular targets at the microtubule plus-end are not understood. Using DNA origami–based reconstructions, we show that clusters of human CLASP2 form a load-bearing bond with terminal non-GT...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812398/ https://www.ncbi.nlm.nih.gov/pubmed/36598991 http://dx.doi.org/10.1126/sciadv.abq5404 |