CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state–sensitive manner

CLASPs (cytoplasmic linker-associated proteins) are ubiquitous stabilizers of microtubule dynamics, but their molecular targets at the microtubule plus-end are not understood. Using DNA origami–based reconstructions, we show that clusters of human CLASP2 form a load-bearing bond with terminal non-GT...

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Detalles Bibliográficos
Autores principales: Luo, Wangxi, Demidov, Vladimir, Shen, Qi, Girão, Hugo, Chakraborty, Manas, Maiorov, Aleksandr, Ataullakhanov, Fazly I., Lin, Chenxiang, Maiato, Helder, Grishchuk, Ekaterina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812398/
https://www.ncbi.nlm.nih.gov/pubmed/36598991
http://dx.doi.org/10.1126/sciadv.abq5404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812398/
https://www.ncbi.nlm.nih.gov/pubmed/36598991
http://dx.doi.org/10.1126/sciadv.abq5404

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