CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis

ICOS/ICOSL and CD28/B7-1/B7-2 are T cell co-stimulators and CTLA-4 is an immune checkpoint inhibitor that play critical roles in the pathogenesis of neoplasia. Chitinase 3-like-1 (CHI3L1) is induced in many cancers where it portends a poor prognosis and contributes to tumor metastasis. Here we demon...

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Detalles Bibliográficos
Autores principales: Ma, Bing, Kamle, Suchitra, Akosman, Bedia, Khan, Hina, Lee, Chang-Min, Lee, Chun Geun, Elias, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812560/
https://www.ncbi.nlm.nih.gov/pubmed/36618349
http://dx.doi.org/10.3389/fimmu.2022.1056397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812560/
https://www.ncbi.nlm.nih.gov/pubmed/36618349
http://dx.doi.org/10.3389/fimmu.2022.1056397

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