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CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis

ICOS/ICOSL and CD28/B7-1/B7-2 are T cell co-stimulators and CTLA-4 is an immune checkpoint inhibitor that play critical roles in the pathogenesis of neoplasia. Chitinase 3-like-1 (CHI3L1) is induced in many cancers where it portends a poor prognosis and contributes to tumor metastasis. Here we demon...

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Detalles Bibliográficos
Autores principales:	Ma, Bing, Kamle, Suchitra, Akosman, Bedia, Khan, Hina, Lee, Chang-Min, Lee, Chun Geun, Elias, Jack A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812560/ https://www.ncbi.nlm.nih.gov/pubmed/36618349 http://dx.doi.org/10.3389/fimmu.2022.1056397

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