Cargando…

The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review

Phosphodiesterase-1 (PDE1) is a versatile enzyme that has surprisingly received considerable attention as a possible therapeutic target in Alzheimer’s disease (AD) because it maintains the homeostasis of 3ʹ,5ʹ-cyclic adenosine monophosphate (cAMP) and 3ʹ,5ʹ-cyclic guanosine monophosphate (cGMP) in t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmad, Nazir, Lesa, Kaisun Nesa, Sudarmanto, Ari, Fakhrudin, Nanang, Ikawati, Zullies
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812569/ https://www.ncbi.nlm.nih.gov/pubmed/36618909 http://dx.doi.org/10.3389/fphar.2022.1070677

Ejemplares similares

The importance of ARG513 as a hydrogen bond anchor to discover COX-2 inhibitors in a virtual screening campaign
por: Yuniarti, Nunung, et al.
Publicado: (2011)

Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants
por: Tiwari, Amit K., et al.
Publicado: (2013)

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases
por: Li, Heng, et al.
Publicado: (2018)

Phosphodiesterase 4 Inhibitors in Allergic Rhinitis/Rhinosinusitis
por: Janosova, Viera, et al.
Publicado: (2020)

Respiratory Cilia as a Therapeutic Target of Phosphodiesterase Inhibitors
por: Joskova, Marta, et al.
Publicado: (2020)

Phosphodiesterase-4 Inhibitors for Non-COPD Respiratory Diseases
por: Kawamatawong, Theerasuk
Publicado: (2021)

The efficient use of smartphone apps to improve the level of asthma knowledge
por: Ghozali, Muhammad Thesa, et al.
Publicado: (2022)

Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage
por: Ningrum, Vitarani D.A., et al.
Publicado: (2018)

Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases
por: Phillips, Jonathan E.
Publicado: (2020)

Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors
por: Lee, Sang-Yong, et al.
Publicado: (2017)

The Effect of Phosphodiesterase-type 5 Inhibitors on Erectile Function: An Overview of Systematic Reviews
por: Pyrgidis, Nikolaos, et al.
Publicado: (2021)

Recent developments of phosphodiesterase inhibitors: Clinical trials, emerging indications and novel molecules
por: Bondarev, Andrey D., et al.
Publicado: (2022)

Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy
por: dos Santos, Thaiane Coelho, et al.
Publicado: (2018)

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease
por: Shal, Bushra, et al.
Publicado: (2018)

Editorial: Natural Product Epigenetic Modulators and Inhibitors
por: Ntie-Kang, Fidele, et al.
Publicado: (2021)

The influence of metformin transporter gene SLC22A1 and SLC47A1 variants on steady-state pharmacokinetics and glycemic response
por: Ningrum, Vitarani Dwi Ananda, et al.
Publicado: (2022)

Antiangiogenic Activity of n-hexane Insoluble Fraction and Its Tylophorine Component from Ficus septica Leaves in Chicken Chorioallantoic Membrane Induced by bFGF
por: Nurhasanah, Devika, et al.
Publicado: (2023)

Editorial: Phosphodiesterases as Drug Targets in Airway and Inflammatory Diseases
por: Mokry, Juraj, et al.
Publicado: (2021)

East Indian Sandalwood Oil Is a Phosphodiesterase Inhibitor: A New Therapeutic Option in the Treatment of Inflammatory Skin Disease
por: Sharma, Manju, et al.
Publicado: (2018)

In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis
por: Silva, Dahara Keyse Carvalho, et al.
Publicado: (2020)

The Natural Polypeptides as Significant Elastase Inhibitors
por: Ahmad, Shabir, et al.
Publicado: (2020)

Editorial: Cyclic Nucleotide Phosphodiesterases (PDEs) in Immune Regulation and Inflammation
por: Brocke, Stefan, et al.
Publicado: (2022)

Editorial: Treatment of Alzheimer’s disease-discovery of natural products based on neurite outgrowth and neuroprotection
por: Yang, Zhiyou, et al.
Publicado: (2022)

A novel strategy for bioactive natural products targeting NLRP3 inflammasome in Alzheimer’s disease
por: Yang, Zhiyou, et al.
Publicado: (2023)

Reversal of spatial memory impairment by phosphodiesterase 3 inhibitor cilostazol is associated with reduced neuroinflammation and increased cerebral glucose uptake in aged male mice
por: Yanai, Shuichi, et al.
Publicado: (2022)

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

Identification of Natural Products as SENP2 Inhibitors for Targeted Therapy in Heart Failure
por: Taghvaei, Somayye, et al.
Publicado: (2022)

Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products
por: Du, Yue, et al.
Publicado: (2022)

Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer's Disease
por: Deng, Yin-Hua, et al.
Publicado: (2017)

Editorial: Natural Products-Based Drugs: Potential Therapeutics Against Alzheimer’s Disease and Other Neurological Disorders
por: Ayaz, Muhammad, et al.
Publicado: (2019)

Phosphodiesterase 9 (PDE9) regulates bovine tracheal smooth muscle relaxation
por: TAJIMA, Tsuyoshi, et al.
Publicado: (2018)

Type-4 Phosphodiesterase (PDE4) Blockade Reduces NETosis in Cystic Fibrosis
por: Totani, Licia, et al.
Publicado: (2021)

Therapeutic Effects of Natural Drugs on Alzheimer’s Disease
por: Ma, Yuan, et al.
Publicado: (2019)

Raging the War Against Inflammation With Natural Products
por: Attiq, Ali, et al.
Publicado: (2018)

Mechanism of Neural Regeneration Induced by Natural Product LY01 in the 5×FAD Mouse Model of Alzheimer’s Disease
por: Li, Xiao-Wan, et al.
Publicado: (2022)

Contribution of sewage to occurrence of phosphodiesterase-5 inhibitors in natural water
por: Hong, Youngmin, et al.
Publicado: (2021)

Editorial: The Role of Natural Products in Chronic Inflammation
por: Deng, Wenjun, et al.
Publicado: (2022)

The multifaceted roles of natural products in mitochondrial dysfunction
por: Chen, Qianrun, et al.
Publicado: (2023)

Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells
por: Adderley, Shaquria P., et al.
Publicado: (2012)

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease
por: Long, Hui-Zhi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bj1qk3ss1hr1tk7ptfb3ciclbv