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Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats

Using a well-established chronic visceral hypersensitivity (VH) rat model, we characterized the decrease of myelin basic protein, reduced number of mature oligodendrocytes (OLs), and hypomyelination in the anterior cingulate cortex (ACC). The results of rat gambling test showed impaired decision-mak...

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Detalles Bibliográficos
Autores principales: Hasan, Mahadi, Lei, Zhuogui, Akter, Mastura, Iqbal, Zafar, Usaila, Faeeqa, Ramkrishnan, Aruna Surendran, Li, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812719/
https://www.ncbi.nlm.nih.gov/pubmed/36619970
http://dx.doi.org/10.1016/j.isci.2022.105840