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Adenosine A(2A) receptor availability in patients with early- and moderate-stage Parkinson’s disease

INTRODUCTION: Adenosine 2A (A(2A)) receptors co-localize with dopamine D(2 )receptors in striatopallidal medium spiny neurons of the indirect pathway. A(2A) receptor activation in the striatum or pallidum decreases D(2 )signaling. In contrast, A(2A) receptor antagonism may help potentiate it. Furthe...

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Detalles Bibliográficos
Autores principales: Waggan, Imran, Rissanen, Eero, Tuisku, Jouni, Joutsa, Juho, Helin, Semi, Parkkola, Riitta, Rinne, Juha O., Airas, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813038/
https://www.ncbi.nlm.nih.gov/pubmed/36053386
http://dx.doi.org/10.1007/s00415-022-11342-1