Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers

Histone lysine-specific methyltransferase 2 (KMT2A-D) proteins, alternatively called mixed lineage leukemia (MLL1-4) proteins, mediate positive transcriptional memory. Acting as the catalytic subunits of human COMPASS-like complexes, KMT2A-D methylate H3K4 at promoters and enhancers. KMT2A-D contain...

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Detalles Bibliográficos
Autores principales: Stroynowska-Czerwinska, Anna Maria, Klimczak, Magdalena, Pastor, Michal, Kazrani, Asgar Abbas, Misztal, Katarzyna, Bochtler, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813062/
https://www.ncbi.nlm.nih.gov/pubmed/36598580
http://dx.doi.org/10.1007/s00018-022-04651-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813062/
https://www.ncbi.nlm.nih.gov/pubmed/36598580
http://dx.doi.org/10.1007/s00018-022-04651-1

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