Profilin 1 deficiency drives mitotic defects and reduces genome stability

Profilin 1—encoded by PFN1—is a small actin-binding protein with a tumour suppressive role in various adenocarcinomas and pagetic osteosarcomas. However, its contribution to tumour development is not fully understood. Using fix and live cell imaging, we report that Profilin 1 inactivation results in...

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Detalles Bibliográficos
Autores principales: Scotto di Carlo, Federica, Russo, Sharon, Muyas, Francesc, Mangini, Maria, Garribba, Lorenza, Pazzaglia, Laura, Genesio, Rita, Biamonte, Flavia, De Luca, Anna Chiara, Santaguida, Stefano, Scotlandi, Katia, Cortés-Ciriano, Isidro, Gianfrancesco, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813376/
https://www.ncbi.nlm.nih.gov/pubmed/36599901
http://dx.doi.org/10.1038/s42003-022-04392-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813376/
https://www.ncbi.nlm.nih.gov/pubmed/36599901
http://dx.doi.org/10.1038/s42003-022-04392-8

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