The inhibition of PGAM5 suppresses seizures in a kainate-induced epilepsy model via mitophagy reduction

BACKGROUND: Epilepsy is a common neurological disease, and excessive mitophagy is considered as one of the major triggers of epilepsy. Mitophagy is a crucial pathway affecting reactive oxygen species. Phosphoglycerate mutase 5 (PGAM5) is a protein phosphatase present in mitochondria that regulates m...

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Detalles Bibliográficos
Autores principales: Zhong, Fuxin, Gan, Yunhao, Song, Jiaqi, Zhang, Wenbo, Yuan, Shiyun, Qin, Zhangjin, Wu, Jiani, Lü, Yang, Yu, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813404/
https://www.ncbi.nlm.nih.gov/pubmed/36618822
http://dx.doi.org/10.3389/fnmol.2022.1047801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813404/
https://www.ncbi.nlm.nih.gov/pubmed/36618822
http://dx.doi.org/10.3389/fnmol.2022.1047801

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