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Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury

Mechanical strain contributes to ventilator-induced lung injury (VILI) through multi-factorial and complex mechanisms that remain unresolved. Prevailing evidence suggests that the loss of pulmonary endothelial tight junctions (TJs) plays a critical role. TJs are dynamically regulated by physiologic...

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Detalles Bibliográficos
Autores principales: Garcia-Flores, Alejandro E., Gross, Christine M., Zemskov, Evgeny A., Lu, Qing, Tieu, Kim, Wang, Ting, Black, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813411/
https://www.ncbi.nlm.nih.gov/pubmed/36620216
http://dx.doi.org/10.3389/fphys.2022.1066515