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Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio
The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and synthesizes the second messenger, cGAMP, thus activating the adaptor protein stimulator of interferon genes (STING) and initiating the innate immune responses against microbial infections. cGAS-STING pathway has been crucially i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813507/ https://www.ncbi.nlm.nih.gov/pubmed/36619988 http://dx.doi.org/10.3389/fmicb.2022.1065945 |
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author | Lu, Zengzeng Fu, Yuqian Zhou, Xueyuan Du, Hekang Chen, Qi |
author_facet | Lu, Zengzeng Fu, Yuqian Zhou, Xueyuan Du, Hekang Chen, Qi |
author_sort | Lu, Zengzeng |
collection | PubMed |
description | The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and synthesizes the second messenger, cGAMP, thus activating the adaptor protein stimulator of interferon genes (STING) and initiating the innate immune responses against microbial infections. cGAS-STING pathway has been crucially implicated in autoimmune diseases, cellular senescence, and cancer immunotherapy, while the cGAS-like receptors in bacteria can protect it against viral infections. Dinucleotide cyclase in Vibrio (DncV) is a dinucleotide cyclase originally identified in Vibrio cholerae. The synthesis of cyclic nucleotides by DncV, including c-di-GMP, c-di-AMP, and cGAMP mediates bacterial colonization, cell membrane formation, and virulence. DncV is a structural and functional homolog of the mammalian cytoplasmic DNA sensor, cGAS, implicating cGAS-STING signaling cascades may have originated in the bacterial immune system. Herein, we summarize the roles of DncV in bacterial immunity, which are expected to provide insights into the evolution of cGAS-STING signaling. |
format | Online Article Text |
id | pubmed-9813507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98135072023-01-06 Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio Lu, Zengzeng Fu, Yuqian Zhou, Xueyuan Du, Hekang Chen, Qi Front Microbiol Microbiology The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and synthesizes the second messenger, cGAMP, thus activating the adaptor protein stimulator of interferon genes (STING) and initiating the innate immune responses against microbial infections. cGAS-STING pathway has been crucially implicated in autoimmune diseases, cellular senescence, and cancer immunotherapy, while the cGAS-like receptors in bacteria can protect it against viral infections. Dinucleotide cyclase in Vibrio (DncV) is a dinucleotide cyclase originally identified in Vibrio cholerae. The synthesis of cyclic nucleotides by DncV, including c-di-GMP, c-di-AMP, and cGAMP mediates bacterial colonization, cell membrane formation, and virulence. DncV is a structural and functional homolog of the mammalian cytoplasmic DNA sensor, cGAS, implicating cGAS-STING signaling cascades may have originated in the bacterial immune system. Herein, we summarize the roles of DncV in bacterial immunity, which are expected to provide insights into the evolution of cGAS-STING signaling. Frontiers Media S.A. 2022-12-22 /pmc/articles/PMC9813507/ /pubmed/36619988 http://dx.doi.org/10.3389/fmicb.2022.1065945 Text en Copyright © 2022 Lu, Fu, Zhou, Du and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Lu, Zengzeng Fu, Yuqian Zhou, Xueyuan Du, Hekang Chen, Qi Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio |
title | Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio |
title_full | Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio |
title_fullStr | Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio |
title_full_unstemmed | Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio |
title_short | Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio |
title_sort | cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in vibrio |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813507/ https://www.ncbi.nlm.nih.gov/pubmed/36619988 http://dx.doi.org/10.3389/fmicb.2022.1065945 |
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