Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B–deficient mice

Mice lacking the immunoreceptor tyrosine-based inhibition motif-containing co-inhibitory receptor G6b-B (Mpig6b, G6b knockout, KO) are born with a complex megakaryocyte (MK) per platelet phenotype, characterized by severe macrothrombocytopenia, expansion of the MK population, and focal myelofibrosis...

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Detalles Bibliográficos
Autores principales: Mazharian, Alexandra, Maître, Blandine, Bornert, Alicia, Hennequin, Desline, Lourenco-Rodrigues, Marc, Geer, Mitchell J., Smith, Christopher W., Heising, Silke, Walter, Michaela, Montel, Florian, Walker, Lucy S. K., de la Salle, Henri, Watson, Steve P., Gachet, Christian, Senis, Yotis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813534/
https://www.ncbi.nlm.nih.gov/pubmed/36269841
http://dx.doi.org/10.1182/bloodadvances.2022008873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813534/
https://www.ncbi.nlm.nih.gov/pubmed/36269841
http://dx.doi.org/10.1182/bloodadvances.2022008873

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