Chemically modified small interfering RNA targeting Hedgehog signaling pathway for rheumatoid arthritis therapy

Rheumatoid arthritis (RA) is an inflammatory disease that leads to disability; however, existing therapies are still unsatisfactory. Activated fibroblast-like synoviocytes (FLSs) play an essential role in synovitis formation and joint destruction in RA. The Hedgehog signaling pathway is aberrantly a...

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Detalles Bibliográficos
Autores principales: Lin, Lang, Zhu, Shangling, Huang, Hongyu, Wu, Lin-Ping, Huang, Jianlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813581/
https://www.ncbi.nlm.nih.gov/pubmed/36618268
http://dx.doi.org/10.1016/j.omtn.2022.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813581/
https://www.ncbi.nlm.nih.gov/pubmed/36618268
http://dx.doi.org/10.1016/j.omtn.2022.12.008

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