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Chemically modified small interfering RNA targeting Hedgehog signaling pathway for rheumatoid arthritis therapy
Rheumatoid arthritis (RA) is an inflammatory disease that leads to disability; however, existing therapies are still unsatisfactory. Activated fibroblast-like synoviocytes (FLSs) play an essential role in synovitis formation and joint destruction in RA. The Hedgehog signaling pathway is aberrantly a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813581/ https://www.ncbi.nlm.nih.gov/pubmed/36618268 http://dx.doi.org/10.1016/j.omtn.2022.12.008 |