Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice

Alzheimer’s disease (AD) genetics studies have identified a coding variant within ABI3 gene that increases the risk of developing AD. Recently, we demonstrated that deletion of the Abi3 gene locus dramatically exacerbates AD neuropathology in a transgenic mouse model of amyloidosis. In the course of...

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Detalles Bibliográficos
Autores principales: Smith, Daniel C., Karahan, Hande, Wijeratne, H. R. Sagara, Al-Amin, Mamun, McCord, Brianne, Moon, Younghye, Kim, Jungsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813750/
https://www.ncbi.nlm.nih.gov/pubmed/36620768
http://dx.doi.org/10.3389/fnagi.2022.1035572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813750/
https://www.ncbi.nlm.nih.gov/pubmed/36620768
http://dx.doi.org/10.3389/fnagi.2022.1035572

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