Cosolvent Dimethyl Sulfoxide Influences Protein–Ligand Binding Kinetics via Solvent Viscosity Effects: Revealing the Success Rate of Complex Formation Following Diffusive Protein–Ligand Encounter

[Image: see text] Protein–ligand-exchange kinetics determines the duration of biochemical signals and consequently plays an important role in drug design. Binding studies commonly require solubilization of designed ligands in solvents such as dimethyl sulfoxide (DMSO), resulting in residual amounts...

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Detalles Bibliográficos
Autores principales: Wernersson, Sven, Birgersson, Simon, Akke, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813907/
https://www.ncbi.nlm.nih.gov/pubmed/36542811
http://dx.doi.org/10.1021/acs.biochem.2c00507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813907/
https://www.ncbi.nlm.nih.gov/pubmed/36542811
http://dx.doi.org/10.1021/acs.biochem.2c00507

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