Discovering and harnessing oxidative enzymes for chemoenzymatic synthesis and diversification of anticancer camptothecin analogues

Semi-synthetic derivatives of camptothecin, a quinoline alkaloid found in the Camptotheca acuminata tree, are potent anticancer agents. Here we discovered two C. acuminata cytochrome P450 monooxygenases that catalyze regio-specific 10- and 11-oxidations of camptothecin, and demonstrated combinatoria...

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Detalles Bibliográficos
Autores principales: Nguyen, Tuan-Anh M., Nguyen, Trinh-Don, Leung, Yuen Yee, McConnachie, Matthew, Sannikov, Oleg, Xia, Zhicheng, Dang, Thu-Thuy T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814082/
https://www.ncbi.nlm.nih.gov/pubmed/36697859
http://dx.doi.org/10.1038/s42004-021-00602-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814082/
https://www.ncbi.nlm.nih.gov/pubmed/36697859
http://dx.doi.org/10.1038/s42004-021-00602-2

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