Internal water channel formation in CXCR4 is crucial for G(i)-protein coupling upon activation by CXCL12

Chemokine receptor CXCR4 is a major drug target for numerous diseases because of its involvement in the regulation of cell migration and the developmental process. In this study, atomic-level molecular dynamics simulations were used to determine the activation mechanism and internal water formation...

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Detalles Bibliográficos
Autores principales: Chang, Chun-Chun, Liou, Je-Wen, Dass, Kingsley Theras Primus, Li, Ya-Tzu, Jiang, Shinn-Jong, Pan, Sheng-Feng, Yeh, Yu-Chen, Hsu, Hao-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814148/
https://www.ncbi.nlm.nih.gov/pubmed/36703316
http://dx.doi.org/10.1038/s42004-020-00383-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814148/
https://www.ncbi.nlm.nih.gov/pubmed/36703316
http://dx.doi.org/10.1038/s42004-020-00383-0

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