Targeting undruggable carbohydrate recognition sites through focused fragment library design

Carbohydrate-protein interactions are key for cell-cell and host-pathogen recognition and thus, emerged as viable therapeutic targets. However, their hydrophilic nature poses major limitations to the conventional development of drug-like inhibitors. To address this shortcoming, four fragment librari...

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Detalles Bibliográficos
Autores principales: Shanina, Elena, Kuhaudomlarp, Sakonwan, Siebs, Eike, Fuchsberger, Felix F., Denis, Maxime, da Silva Figueiredo Celestino Gomes, Priscila, Clausen, Mads H., Seeberger, Peter H., Rognan, Didier, Titz, Alexander, Imberty, Anne, Rademacher, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814205/
https://www.ncbi.nlm.nih.gov/pubmed/36697615
http://dx.doi.org/10.1038/s42004-022-00679-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814205/
https://www.ncbi.nlm.nih.gov/pubmed/36697615
http://dx.doi.org/10.1038/s42004-022-00679-3

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