Single step syntheses of (1S)-aryl-tetrahydroisoquinolines by norcoclaurine synthases

The 1-aryl-tetrahydroisoquinoline (1-aryl-THIQ) moiety is found in many biologically active molecules. Single enantiomer chemical syntheses are challenging and although some biocatalytic routes have been reported, the substrate scope is limited to certain structural motifs. The enzyme norcoclaurine...

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Detalles Bibliográficos
Autores principales: Roddan, Rebecca, Sula, Altin, Méndez-Sánchez, Daniel, Subrizi, Fabiana, Lichman, Benjamin R., Broomfield, Joseph, Richter, Michael, Andexer, Jennifer N., Ward, John M., Keep, Nicholas H., Hailes, Helen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814250/
https://www.ncbi.nlm.nih.gov/pubmed/36703392
http://dx.doi.org/10.1038/s42004-020-00416-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814250/
https://www.ncbi.nlm.nih.gov/pubmed/36703392
http://dx.doi.org/10.1038/s42004-020-00416-8

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