Proton transfer during DNA strand separation as a source of mutagenic guanine-cytosine tautomers

Proton transfer between the DNA bases can lead to mutagenic Guanine-Cytosine tautomers. Over the past several decades, a heated debate has emerged over the biological impact of tautomeric forms. Here, we determine that the energy required for generating tautomers radically changes during the separat...

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Detalles Bibliográficos
Autores principales: Slocombe, Louie, Winokan, Max, Al-Khalili, Jim, Sacchi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814255/
https://www.ncbi.nlm.nih.gov/pubmed/36697962
http://dx.doi.org/10.1038/s42004-022-00760-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814255/
https://www.ncbi.nlm.nih.gov/pubmed/36697962
http://dx.doi.org/10.1038/s42004-022-00760-x

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