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Proton transfer during DNA strand separation as a source of mutagenic guanine-cytosine tautomers
Proton transfer between the DNA bases can lead to mutagenic Guanine-Cytosine tautomers. Over the past several decades, a heated debate has emerged over the biological impact of tautomeric forms. Here, we determine that the energy required for generating tautomers radically changes during the separat...
Autores principales: | Slocombe, Louie, Winokan, Max, Al-Khalili, Jim, Sacchi, Marco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814255/ https://www.ncbi.nlm.nih.gov/pubmed/36697962 http://dx.doi.org/10.1038/s42004-022-00760-x |
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