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Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease
Membrane proteins are frequently modulated by specific protein-lipid interactions. The activation of human inward rectifying potassium (hKir) channels by phosphoinositides (PI) has been well characterised. Here, we apply a coarse-grained molecular dynamics free-energy perturbation (CG-FEP) protocol...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814360/ https://www.ncbi.nlm.nih.gov/pubmed/36703430 http://dx.doi.org/10.1038/s42004-020-00391-0 |