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Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease

Membrane proteins are frequently modulated by specific protein-lipid interactions. The activation of human inward rectifying potassium (hKir) channels by phosphoinositides (PI) has been well characterised. Here, we apply a coarse-grained molecular dynamics free-energy perturbation (CG-FEP) protocol...

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Detalles Bibliográficos
Autores principales:	Pipatpolkai, Tanadet, Corey, Robin A., Proks, Peter, Ashcroft, Frances M., Stansfeld, Phillip J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814360/ https://www.ncbi.nlm.nih.gov/pubmed/36703430 http://dx.doi.org/10.1038/s42004-020-00391-0

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